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M9480559.TXT
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1994-08-20
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Document 0559
DOCN M9480559
TI Luffin-S--a small novel ribosome-inactivating protein from Luffa
cylindrica. Characterization and mechanism studies.
DT 9410
AU Gao W; Ling J; Zhong X; Liu W; Zhang R; Yang H; Cao H; Zhang Z; Shanghai
Institute of Biochemistry, Academia Sinica, P.R. China.
SO FEBS Lett. 1994 Jun 27;347(2-3):257-60. Unique Identifier : AIDSLINE
MED/94307395
AB We purified and characterized a novel RIP (ribosome inactivating
protein), Luffin-S from the seeds of Luffa cylindrica. Different from
Luffin-A and B, which are RNA N-glycosidases with molecular weights of
27 and 28 kDa, respectively, Luffin-S has an M.W. of only approx. 10
kDa, much smaller than any other RIPs so far investigated. Its abundant
resources, toxicity similar to TCS in a cell-free protein synthesis
system and unique mechanism as phosphodiesterase, like alpha-sarcin,
promisingly make it a potential toxic moiety of immunotoxin.
DE Amino Acids/ANALYSIS Animal Cell-Free System Comparative Study Drug
Stability Electrophoresis, Polyacrylamide Gel Fungal
Proteins/ANALYSIS/METABOLISM Heat HIV-1/DRUG EFFECTS Molecular Weight
Phosphoric Diester Hydrolases/*ISOLATION & PURIF/METABOLISM/
PHARMACOLOGY Plant Proteins/*ISOLATION & PURIF/METABOLISM/PHARMACOLOGY
Protein Synthesis Inhibitors Rabbits Ribonuclease,
Pancreatic/ANALYSIS/METABOLISM Ribosomes/*DRUG EFFECTS RNA,
Ribosomal/METABOLISM Seeds/*CHEMISTRY JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).